Advanced technologies for transdermal drug Delivery system: A review

Manasa T G, S Rajarajan, Beny Baby, K Ramesh

Transdermal drug delivery systems (TDDS) represent a significant advancement in pharmacological therapies, offering a non-invasive method for drug administration that enhances patient compliance and minimizes systemic side effects. This review discusses the traditional challenges associated with drug delivery, including poor bioavailability and first-pass metabolism, and highlights innovative technologies designed to improve drug permeability and controlled release. Key advancements such as vesicular systems, microneedles, iontophoresis, and nano-formulations are explored for their roles in overcoming the stratum corneum barrier. The integration of smart patches, AI-driven optimization, and 3D printing for personalized dosages also shows promise in revolutionizing patient care. By leveraging these advanced technologies, TDDS can potentially become a cornerstone of modern medicine, offering efficient and effective alternatives to conventional drug administration methods.

Keywords –Transdermal Drug Delivery System, Drug Permeability, Smart Patches, Microneedles, Iontophoresis, Bioavailability.